Advances in Parasitology, Vol. 58 - download pdf or read online

By John R. Baker, Ralph Muller, David Rollinson

ISBN-10: 0120317583

ISBN-13: 9780120317585

The Advances in Parasitology sequence includes in-depth studies on present themes of curiosity in modern parasitology. It comprises scientific experiences on parasites of significant impression, corresponding to trypanosomiasis and scabies, and extra conventional components, akin to zoology, taxonomy, and existence historical past, which form present pondering and functions. * sequence has the second one maximum ISI effect think about the parasitology team! (4.818 in 2002) * members are overseas specialists within the box

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Extra info for Advances in Parasitology, Vol. 58

Sample text

Presence of parasite molecules like glycolipids could disrupt these membrane microdomains (7). -C. ANTOINE ET AL. CD24 expression and the very weak B7-1 expression have been documented for parasite-containing Kupffer cells (resident MÈs of the liver located in the sinusoids) of L. donovani-infected BALB/c mice. Otherwise, these cells express MHC class II molecules. , 1994). In apparent conflict with the preceding data, down regulation of T cell-dependent immune responses involving costimulatory molecules and their counter-receptors have also been recently documented in murine L.

2. -C. ANTOINE ET AL. MHC II Ag Presentation As for the generation of MHC I–peptide complexes, several pathways involved in the formation of MHC class II–peptide complexes have been described. After their synthesis in the RER of APCs, MHC class II molecules that are composed of two transmembrane chains and reach the Golgi apparatus and then the trans-Golgi network in association with transmembrane invariant chains Ii. Ii chains are endowed with important functions since they play a chaperone role for class II molecules, they block the peptide-binding groove of the latter and they allow their targeting from the trans-Golgi network to early or late endosomes.

Figure 4 Ultrastructural aspect of a bone marrow-derived MÈ infected 18 h before with L. amazonensis metacyclic promastigotes. Parasites that have already started their differentiation into amastigotes are located in a huge communal PV. One hour before fixation, cells were incubated with horseradish peroxidase (HRP, 25 mg/ml) to load endosomes and lysosomes. Cells were then fixed and processed for peroxidase cytochemistry before embedding. HRP-containing endosomes/lysosomes (arrows) fuse with PV as indicated by the electron dense product present in the PV lumen.

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Advances in Parasitology, Vol. 58 by John R. Baker, Ralph Muller, David Rollinson

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