Advances in Human Genetics 9 by David G. Harnden, A. M. R. Taylor (auth.), Harry Harris, PDF

By David G. Harnden, A. M. R. Taylor (auth.), Harry Harris, Kurt Hirschhorn (eds.)

ISBN-10: 1461582768

ISBN-13: 9781461582762

ISBN-10: 1461582784

ISBN-13: 9781461582786

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It seems likely that only a much more detailed understanding of the nature of chromosome aberration in molecular terms and of the relationship between aberrations that persist and the function of specific loci will yield information that will elucidate the significance of induced aberrations for cancer. TECHNICAL CONSIDERATIONS IN STUDYING THE CHROMOSOMES OF TUMOR CELLS Bearing in mind that neoplasia is an abnormality of the control of cell division and that a histological feature of many tumors is the presence of numerous mitoses, it is surprising that it is so often difficult to get adequate numbers of well-preserved and well-stained cells in which to study the chromosomes of tumor cells.

In banded preparations, they may be definable in terms of translocations or of some other rearrangement of the normal chromosomes. Sometimes part of a chromosome can be recognized and the remaining part of it, even quite a large region with a distinctive banding pattern, cannot be recognized as having come from any particular normal chromosome. Of course, some of these abnormal chromosomes are of completely unknown origin. , both parts of a reciprocal translocation present), it is reasonably easy to deduce the origin of the component parts, but when only one of the derived chromosomes is present, this determination can be extremely difficult.

At the other extreme, there is one report of a PhI+ve clone arising within a preexisting aneuploid population of leukemic cells. I4I This finding could suggest that the extent of the PhI-containing clone may very considerably from case to case. Chapter 1: Chromosomes and Neoplasia 37 Specificity of Additional Changes Seen in Chronic Myeloid Leukemia In addition to the various translocations reported in CML, further aberrations occur in a proportion of cases. 148,242,246 Many of them appear to be random, but certain other abnormalities occur more frequently than can be expected by chance.

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Advances in Human Genetics 9 by David G. Harnden, A. M. R. Taylor (auth.), Harry Harris, Kurt Hirschhorn (eds.)

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